What is it about?
The heterogeneous nuclear ribinucleoproteins (hnRNPs) are dominant regulators of multiple molecular processes in eukaryotes. The present work explores the evolutionary patterns of functional similarities and diversification of hnRNPs along with their interacting proteins.
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Why is it important?
Post-transcriptional gene regulatory processes have a major impact on fine-tuning the gene expression patterns. hnRNPs are among central regulators of post-transcriptional processes in eukaryotes. The aberrant functioning of human hnRNPs is associated with multiple diseases. A holistic understanding of their functions across species would be of fundamental scientific interest.
Perspectives
hnRNPs are ubiquitous in eukaryotes. A comprehensive analysis of their functions across eukaryotes would be of scientific interest. Most studies so far have focused on the major model organisms. The present computational studies could stimulate further research towards a clearer understanding of their functional conservation and diversification across species.
Dr Nishanth M J
St Joseph's University
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This page is a summary of: Evolutionary Analysis of the hnRNP Interactomes and Their Functions in Eukaryotes, Biochemical Genetics, November 2024, Springer Science + Business Media,
DOI: 10.1007/s10528-024-10956-6.
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