What is it about?
The anti-tuberculosis drug SQ109 is able to kill Leishmania donovani amastigotes inside macrophagues. Tne mechanism of action of the drug is shown. The drug directly affects acidocalcisomes of the parasite and collapse the mitochondrial electrochemical membrane potential. This drives to a large increase in the intracellular calcium concentration
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Why is it important?
SQ109 Is very potent against these parasites since the IC50 fos amastigotes inside macrophages is very low (around 7 nM).
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This page is a summary of: SQ109 inhibits proliferation of Leishmania donovani by disruption of intracellular Ca2+ homeostasis, collapsing the mitochondrial electrochemical potential (ΔΨm) and affecting acidocalcisomes, Zeitschrift für Parasitenkunde Parasitology Research, January 2020, Springer Science + Business Media,
DOI: 10.1007/s00436-019-06560-y.
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