What is it about?
Signalling by inhibitory and activating receptors by interaction with their ligands will determine whether the NK cell becomes activated and kills the target cell. Here, we show reduced expression of NKp46, NKp30, DNAM-1, CD244 and CD94/NKG2C activating receptors on NK cells from acute myeloid leukaemia patients.
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Why is it important?
A better knowledge of the activating receptor repertoire on NK cells and their putative ligands on blasts together with the possibility to modulate their expression will open new possibilities for the use of NK cells in immunotherapy against leukaemia.
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This page is a summary of: Human NK cells in acute myeloid leukaemia patients: analysis of NK cell-activating receptors and their ligands, Cancer Immunology Immunotherapy, June 2011, Springer Science + Business Media,
DOI: 10.1007/s00262-011-1050-2.
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