What is it about?
NKRs can regulate the lysis of target cells expressing appropriate ligands. Activating receptors recognise ligands on tumours whereas inhibitory receptors are specific for MHC class I antigens and sense missing self. Altered expression of MHC class I antigens is frequently found on melanoma cells, preventing recognition by specific cytolytic T cells but favouring NK cell recognition.
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Why is it important?
Changes in the expression of NKR-ligands in melanoma contribute in explaining the differences in the capacity of cytotoxic immune cells to control melanoma growth and dissemination.
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This page is a summary of: Lymphocyte activation in response to melanoma: interaction of NK-associated receptors and their ligands, Cancer Immunology Immunotherapy, February 2006, Springer Science + Business Media,
DOI: 10.1007/s00262-006-0141-y.
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