What is it about?
Oxidative damage due to low levels of glutathione (GSH) is one of the main causes of cataract formation. A cysteine prodrug, 2-oxothiazolidine-4-carboxylic acid (OTZ), can increase the cellular level of GSH. We have developed a method for determining OTZ content and have used this to determine the loading of nanoparticles containing this drug.
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Why is it important?
The paper is a stepping stone to developing therapeutic strategies for treating or preventing cataracts.
Perspectives
A free post-print version is available in the resources section.
Dr James R Smith
University of Portsmouth
Read the Original
This page is a summary of: Analysis of 2-oxothiazolidine-4-carboxylic acid by hydrophilic interaction liquid chromatography: application for ocular delivery using chitosan nanoparticles, Analytical and Bioanalytical Chemistry, February 2015, Springer Science + Business Media,
DOI: 10.1007/s00216-015-8494-8.
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