What is it about?
Chemokines are signaling proteins that induce chemotaxis (attract) in nearby responsive cells. This study demonstrated that after tendon injury chemokines appear early in the tendon proper, which during normal conditions is devoid of chemokines. Following the chemokine expression, inflammatory cells, blood vessels and nerve fibers emerged in the healing proper tendon.
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Why is it important?
The findings of this study suggest that early chemokine expression in tendon healing exhibits a chemoattractant role stimulating ingrowth of new nerves and blood vessels as well as of inflammatory cells, which are essential in tendon repair.
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This page is a summary of: Chemokine expression of CCL2, CCL3, CCL5 and CXCL10 during early inflammatory tendon healing precedes nerve regeneration: an immunohistochemical study in the rat, Knee Surgery Sports Traumatology Arthroscopy, May 2014, Springer Science + Business Media,
DOI: 10.1007/s00167-014-3010-9.
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