What is it about?
Triggering receptor expressed on myeloid cell-1 (TREM-1) is a transmembrane glycoprotein, which is present in the surface of neutrophils and monocytes. Its expression is upregulated in bacterial and fungal infections, as it promotes the release of various proinflammatory cytokines via the activation of the DNA activating protein 12 (DAP12) signaling pathway. There is growing evidence that sTREM-1 is a promising inflammatory biomarker with diagnostic and predictive value in lower respiratory tract infections and adult sepsis. The present meta-analysis aims to accumulate, for the first time, current knowledge in this topic, in order to assess the diagnostic accuracy of serum sTREM-1 in neonatal sepsis.
Featured Image
Why is it important?
The present meta-analysis combined, for the first time, the results of studies evaluating the role of sTREM-1 in the diagnosis of neonatal sepsis. The statistical analysis was conducted with hierarchical models which take into account the effect of sensitivity on the given level of specificity and limit potential bias that may arise from meta-analyses based on the classical Moses‐Littenberg method.
Perspectives
Writing this article gave us the opportunity to familiarize ourselves with hierarchical models, that are relatively novel in the field of medical meta-analyses. We were very enthusiastic about it and await comments for further research.
Dr Vasilios Pergialiotis
National and Kapodistrian University of Athens
Read the Original
This page is a summary of: Soluble TREM-1 as a predictive factor of neonatal sepsis: a meta-analysis, Inflammation Research, April 2018, Springer Science + Business Media,
DOI: 10.1007/s00011-018-1149-4.
You can read the full text:
Contributors
The following have contributed to this page
