What is it about?
Ionizing irradiation induced marked morphological alterations in the Purkinje cell axons and axonic terminals in vitro. The myelinated segments demonstrated a very poor development of the myelin sheath. The axoplasm demonstrated various alterations of the mitochondria, and the smooth endoplasmic reticulum and the numerous elongated presynaptic terminals contained large aggregates of tubulovesicular structures and neurofilaments arranged in parallel and reticular array.
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Why is it important?
The ionizing irradiation seemed to interfere either in the mechanism of the conversion of the smooth endoplasmic reticular membranes into synaptic vesicles, or in the normal liberation of the neurotransmitter, due to deorganization of the synaptic formation in the agranular cerebellum, leading to a distruction of the local neuronal circuits. The defective liberation of the neurotransmitter, therefore, leads to a conversion of many synaptic vesicles into tubulovesicular profiles.
Perspectives
The axons under ionizing irradiation demonstrate marked morphological alterations. In the large majority of the axonic terminals the number of mitochondria are reduced and sow serious morphological alterations. The tubulovesicular material was almost exclusively seen in the unmyelinated segments of the axons with a higher preponderance in the presynaptic terminals. Almost all the presynaptic terminals contained numerous coated vesicles arranged mostly near the periphery.The tubulovesicular profiles were the most impressive fnding in the nonmyelinated axonal segments and in the presynaptic terminals in the irradiated cerebellar explants.These tubulovesicular profiles presumably arose by an atypical proliferation of the smooth endoplasmic reticulum, which partially failed in the final step of synaptic vesicle recycling
Professor Stavros J Baloyannis or Balogiannis or Balojannis or Baloyiannis or Mpalogiannis
Aristotle University of Thessaloniki
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This page is a summary of: Morphological alterations of Purkinje cell axons and presynaptic terminals in organotypic cerebellar cultures exposed to ionizing irradiation, Acta Neuropathologica, December 1981, Springer Science + Business Media,
DOI: 10.1007/bf00697004.
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