What is it about?
Toxicity assessment is one of the most important steps in the pipeline-development of drugs and agrochemicals. Computational toxicology plays a crucial role in this context and it is very important to keep it updated and well-described regarding key methodologies and software used for this purpose.
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Why is it important?
The unique content of this book chapter brings an updated overview of in silico methods to predict toxicity of bioactive substances, in view of main advantages associated with computational toxicology: reduction of costs and time in development of drugs/agrochemicals; replace of animal testing; adequacy to the standards of regulatory agencies responsible for evaluating the use of these methods as well as approval of these chemicals.
Perspectives
Writing this book chapter was a great pleasure as it has co-authors with whom I have had long standing collaborations, in addition to international collaborators which enriched the approached perspectives herein. I hope it achieves the proper impact and dissemination.
Guilherme Martins Silva
Harvard Medical School
Read the Original
This page is a summary of: In Silico Methods to Predict Relevant Toxicological Endpoints of Bioactive Substances, January 2021, Springer Science + Business Media,
DOI: 10.1007/978-3-030-62226-8_22.
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