What is it about?
Pyroelectric BaTiO3@Au (BTO@Au) core-shell heterostructure was designed to interfere with the metabolism of triple-negative breast cancer (TNBC) cells under near-infrared (NIR) laser irradiation, by which the outer Au shell can absorb NIR light to generate heat, activating the separation of e - and h + in piezoelectric barium titanate (BTO) core to generate abundant reactive oxygen species (ROS) regardless of the tumor microenvironment, breaking the mitochondrial electron transport chain (ETC), inhibiting mitochondrial oxidative phosphorylation (OXPHOS), reducing ATP production in TNBC cells and thereby effectively inhibiting tumor growth.
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Why is it important?
Our findings reveal the critical role of OXPHOS metabolic interventions in the treatment of triple-negative breast cancer, paving a new way for the development of metabolic interventions for TNBC therapy.
Perspectives
This manuscript develops novel pyroelectric BaTiO3@Au core-shell nanostructures (BTO@Au) to selectively and persistently block energy generation of tumor cells, opening up a new avenue for TNBC therapy through metabolic interventions.
Yanlin Feng
Shanxi Medical University
Read the Original
This page is a summary of: BaTiO3@Au nanoheterostructure suppresses triple-negative breast cancer by persistently disrupting mitochondrial energy metabolism, Nano Research, September 2022, Tsinghua University Press,
DOI: 10.1007/s12274-022-4927-9.
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