What is it about?
A review of techniques for surface chemistry modification. This review is intended to give researchers the ability to append biologically relevant interfaces for their research, and it goes in depth about functionalization of microfluidic platforms, hydrogels, noble metals, as well as integration with techniques such as Surface Plasmon Resonance, Electrochemistry, and smart responsive surfaces. This manuscript aims to give researchers the tools to take their research into new and exciting fields to pattern, isolate or interface with cells regardless of their surfaces that they aim to functionalize.
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Why is it important?
The intent of this review is to give researchers the tools that they may need to advance their research into the more biological fields with their research. There remains so much to be delved and discovered in this field and in order to do that, we need more researchers to adapt their research into this space. Hopefully, this review allows researchers who want to get into more biologically relevant research the tools that they need to close the gap between their field and this one.
Perspectives
This manuscript aims to help start to bridge the gap between all of the different fields in the "bioengineering space." As this space is the overlap between other more established fields such as electrical engineering, mechanical engineering, physics, chemistry, biology, material science, and many many others; we run into the problem that it becomes difficult for established researchers or new researchers in these fields to cross the gap into interfacing with biological elements. As we provide the tools and extant literature of how these fields each can be modified slightly to interface with cells, for cell patterning and isolation, we aim to bring more people into the fold, ultimately allowing all of us to have answers to the multitude of questions that we still have within the field.
Ali Ansari
Case Western Reserve University
Read the Original
This page is a summary of: Plenty more room on the glass bottom: Surface functionalization and nanobiotechnology for cell isolation, Nano Research, September 2018, Tsinghua University Press,
DOI: 10.1007/s12274-018-2177-7.
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