What is it about?
We made a relatively large number of nanoparticles that have different types of chemical attached to their surfaces. We studied how the type of chemistry on the surface affects the function of a common enzyme and also how it affects the binding of the nanoparticle to the enzyme surface in general. We found we could explain these two properties very well using a mathematical model
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Why is it important?
The atomic and molecular details of how nanoparticles affect biological systems like cells and organs is not well understood. By tackling this problem systematically, we have been able to decipher some of the design rules for nanomaterials and provide new information on the complex processes involved in nanoparticle interactions. This understanding will be useful for designing new nanomaterials with useful properties, or with little or no adverse effects in biology.
Perspectives
At the time this work was done, it provided the first detailed analysis of how modified nanomaterials affect the function of important human enzymes, and it was one of the first studies to create accurate quantitative and predictive machine learning models of this process.
Professor Dave A Winkler
La Trobe University
Read the Original
This page is a summary of: Probing enzyme-nanoparticle interactions using combinatorial gold nanoparticle libraries, Nano Research, November 2014, Tsinghua University Press,
DOI: 10.1007/s12274-014-0618-5.
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