Modulation of meiotic homologous recombination by DNA helicases

What is it about?

This review summarizes and explicates the the various roles of DNA helicases in meiotic recombination. It discusses the recent progresses being made in meiosis research using the important model organisms Saccharomyces cerevisiae (budding yeast) and Schizosaccharomyces pombe (fission yeast).

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Why is it important?

DNA helicases are main regulators of crucial DNA metabolic processes, including DNA replication, DNA repair, and genetic recombination. This review highlights the function of DNA helicases important for homologous recombination during meiosis, and discusses recent advances in how these modulators of meiotic recombination are themselves regulated.