Effect of human papilloma virus infection onin-vitrofertilization outcome: systematic review and meta-analysis

What is it about?

In a systematic review and meta analysis, we tried tο identify, appraise and summarize the available data, concerning the real impact of HPV infection on the woman and the reproductive outcomes following in vitro fertilization (IVF). After the initial search, we found 14 studies firstly included, but we used quantitative data from 10, evaluating 299 women with HPV infection and 2049 women without HPV infection. After the analysis, we concluded that the available evidence is still insufficient to firmly conclude on the effect of the HPV infection of the woman on the most important reproductive outcomes following IVF. As for the miscarriage rates, we need properly designed and adequately powered studies to confirm the impact of HPV infection. When the infection is present in the male partner, we found that there is a negative effect on live birth/ongoing pregnancy and miscarriage rates, a finding that has to be interpreted with caution, due to the very low quality of evidence supporting it.

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