What is it about?
Los ensayos in vitro mostraron un potencial inmunomodulador de estas vesículas para contrarrestar la diferenciación de las células T CD4 +. Se encontró que la cuantificación de TGFβ activo en EV-endMSCs era muy alta en comparación con los sobrenadantes concentrados libres de vesículas extracelulares. Finalmente, la neutralización de TGFβ atenuó significativamente la actividad inmunomoduladora de EV-endMSC
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Why is it important?
This report showed that EV-endMSCs exhibit a potent inhibitory effect against CD4+ T cell activation, which is partially mediated by TGFβ signalling.
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This page is a summary of: The immunomodulatory activity of extracellular vesicles derived from endometrial mesenchymal stem cells on CD4+ T cells is partially mediated by TGFbeta, Journal of Tissue Engineering and Regenerative Medicine, August 2018, Wiley,
DOI: 10.1002/term.2743.
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