What is it about?
We propose a one-step sample preparation strategy by leveraging label-free impedance flow cytometry (IFC) based microfluidics to solve the problem of simultaneous sorting and desalting of single cells. With this strategy, one only need to flow mixed cell samples into the microfluidic chip, and then get the target cell samples from the outlet for direct single cell MS analysis.
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Why is it important?
With this one-step sample preparation strategy, one do not need to operate with complex equipment and complicated flowcharts. Single-cell MS would be much more efficient.
Perspectives
As an independent standalone sample preparation module, the microfluidic chip is compatible with a variety of MS analysis methods, and envisioned to provide a new paradigm in efficient MS sample preparation, and further in multi-modal (i.e., electrical and metabolicsm) characterization of single cells.
Professor Wenhui Wang
Tsinghua University
Read the Original
This page is a summary of: Microfluidic Impedance Cytometry Enabled One‐Step Sample Preparation for Efficient Single‐Cell Mass Spectrometry, Small, March 2024, Wiley,
DOI: 10.1002/smll.202310700.
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