What is it about?
We used a model human potassium channel that regulates heartbeats to see if there was any interaction with some common nanoparticles (ZnO, SiO2, MgO TiO2). Only ZnO interacted with the ion channel protein and unusually increased the current amplitude. The reaction was rapid (5-20 minutes) and novel.
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Why is it important?
This is one of an increasing number of finding that indicate immediate nanomaterial impact on cell signalling. It is of course occurring alongside the more conventional nano-toxic effects.
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This page is a summary of: Zinc Oxide Nanoparticles and Voltage-Gated Human Kv
11.1 Potassium Channels Interact through a Novel Mechanism, Small, February 2018, Wiley,
DOI: 10.1002/smll.201703403.
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