What is it about?
Examines estimation techniques for pharmacokinetic measurements regarded as unreliable because the concentration is low.
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Why is it important?
Provides theoretical formulae for various approaches that have previously been examined through simulation. Examines the problem through a likelihood framework and shows a connection to the literature on missing observations.
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This page is a summary of: The ghosts of departed quantities: approaches to dealing with observations below the limit of quantitation, Statistics in Medicine, July 2012, Wiley,
DOI: 10.1002/sim.5515.
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