What is it about?

It is concluded that tests of homogeneity on the covariates should not be performed, that covariate imbalance is just as much a problem for large studies as for small ones in terms of effect on size, and that the effect of correlation between covariates and measures of efficacy is complex.

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Why is it important?

It is shown that testing prognostic covariates for lack of balance is an ineffective way to control for their effects.

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This page is a summary of: Covariate imbalance and random allocation in clinical trials, Statistics in Medicine, April 1989, Wiley,
DOI: 10.1002/sim.4780080410.
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