What is it about?
Since the effects of plants on animal diseases are well known, they are widely used in medicine today. This study focused on the preventive effects of the two natural products, as these properties are closely related to the prevention and therapy of diseases. In order to achieve a more rational design of plant therapy, it is necessary to comprehensively clarify the mechanism of plant effects. For this purpose, infusions of Camellia sinensis and Urtica dioica were administered orally as drinking water, since these plants are well characterized in terms of their nutritional values and are widely used as beverages by people in our country and worldwide. The protective effects of raw and pure products of these two plants on some phase II detoxification enzymes, lipid peroxidation, and serum marker enzymes were evaluated during exposure to the chemical carcinogen TCA in rats.
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Why is it important?
Nature is indeed the richest botanical pharmacy created for living beings, and scientific efforts will certainly focus more on "discovering nature" in the future. In the current study, the aqueous plant extract of Camellia sinensis and Urtica dioica may have a chemoprotective effect against carcinogenic exposure in rats. The observations may suggest that such an assay will also be valuable in chemopreventive studies and will be of interest in understanding the molecular basis of the plant's protective role. Nevertheless, the results suggest that regular intake of a naturally occurring combination of anticarcinogens with different biological activities may be useful in preventing chronic degenerative liver disease.
Perspectives
It is now known that many natural products regulate the physiological functions and biotransformation reactions involved in the detoxification process, providing protection against the cytotoxic, genotoxic, and metabolic effects of environmental toxins. In this study, the protective effects of two traditionally used Turkish medicinal plants, Camellia sinensis and Urtica dioica, on carcinogenic trichloroacetic acid exposure were investigated, and the results were eagerly awaited.
Yasin TÜLÜCE
Van Yüzüncü Yıl University
Read the Original
This page is a summary of: Elevation protective role ofCamellia sinensisandUrtica dioicainfusion against trichloroacetic acid-exposed in rats, Phytotherapy Research, July 2007, Wiley,
DOI: 10.1002/ptr.2204.
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