What is it about?
peptide insolubility is structural in origin and is not due to hydrophobicity and yet most approaches to dealing with insolubility do so by adding polar groups. In this paper we show a simple way to improve the solubility and handling properties of your synthetic peptide by substituting the amide bond and disrupting hydrogen bonding.
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This page is a summary of: A backbone amide protecting group for overcoming difficult sequences and suppressing aspartimide formation, Journal of Peptide Science, April 2016, Wiley,
DOI: 10.1002/psc.2877.
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