What is it about?
Water enriched in oxygen -18 is a precursor for the production of radioisotope fluorine-18 used in biomedical applicatons (PET). We have suggested a method suitable for the rapid evaluation of the oxygen isotope content in virgin and recycled 18O-enriched water by NMR: based on the well-known isotope effect of 16O→18O and 16O→17O substitutions on the magnetic shielding of 99Tc nucleus in pertechnetate ion and on the statistical distribution of oxygen isotopes in TcO4–, we can quantify the composition of oxygen-18 enriched water from the relative intensities of the 99Tc NMR signals of Tc16O4 – n18On– isotopologues in aqueous solutions.
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Why is it important?
Due to the high consumption of H218O in PET centers and its high cost, the purification and recovery of enriched water after the cyclotron irradiation for further reuse in the [18F]FDG synthesis is a high‐priority task. Therefore, there is a need to quantify the isotope composition of the recycled water. The suggested original method makes it possible to evaluate the isotope composition of water, which is important for improving enriched water recovery procedures.
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99
Tc NMR determination of the oxygen isotope content in 18
O-enriched water, Magnetic Resonance in Chemistry, December 2017, Wiley,
DOI: 10.1002/mrc.4680.
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