What is it about?
Apparent inconsistencies between features and links of Parkinson´s Disease (PD) pointing to distinct causal interpretations may not be inconsistent. On one side, PD incidence was higher among Faroese immigrants to continental Denmark tan in continental Danish population. In contrast, PD clinical onset was preceded by poor healthy habits requiring public health intervention. An Editorial text in the same MDJ number supported the second view.
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Why is it important?
A description of PD incidences related to age at first major historical whooping-cough epidemic (de Pedro-Cuesta J et al, Int J Epidemiol, 1996 generated by a EU Concerted Action) ) fits a plausible explanation for the findings for Faroese migrants. If so, the long incubation period and subclinical phenomena may explain changes in personality and behavior such as in life habits, as well as result from recall bias.
Perspectives
The paper is about inference between epidemiology and biology of synnucleinopathies, suports an ubiquitous cause of PD, predicts a fall of PD incidence in B. pertussis vaccinated people, and provides a guide for development of seeding models of PD on a causal basis.
Jesús de Pedro-Cuesta
Instituto de Salud Carlos III, Madrid, SPAIN
Read the Original
This page is a summary of: Reconciling etiological views on Parkinson's disease, Movement Disorders, November 2019, Wiley,
DOI: 10.1002/mds.27875.
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