The Utility of Carbon Disulphide and Lawesson's Reagent for Synthesis of Diffe Heterocycles

What is it about?

we explain in this report the reaction of carbon disulfide and LR with hexahydroquinolines , pyrazolopyranes, and pyrazolopyridines. Different bioactive fused heterocycles were synthesized and evaluated as antimicrobial agents

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Why is it important?

Our finding that the synthesized compounds of different fused heterocyclic derivatives exhibit promising antimicrobial activity. Substitution of halo, phosphorous, and sulfurs groups emerged as active in both antibacterial and antifungal screening. Moreover, this preliminary study is encouraging to further explore their broad-spectrum pharmacological activities. The results of antibacterial and fungi studies are given in Table 1. Compound 8d was showed complete inhibition at 30 mm/mg for Escherichia coli (Gram-negative bacteria) and Staphylococcus aureus (Gram-positive bacteria) and showed inhibition at 28 mm/mg higher than the Amphotericin B as antifungal standard for the Candida albicans (Fungus). Compounds 4b and 11b showed moderate inhibition for the two positive and negative bacteria between 22 and 14 mm/mg. The rest of the tested compounds 7a, 11a, and 13b showed moderate inhibition for bacteria between 17 and 13 mm/mg and have 15–11 mm/mg effect on fungi. On the other hand, compound 2a showed low antibacterial inhibition for the two at 10 mm/mg.

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