What is it about?
Quinoline is a benzo-fused pyridine which is a therapeutically important heterocycle in medicinal chemistry research and new drug development. A series of 12 new hydrazide-hydrazone motifs bearing quinoline core 4a-l was successfully synthesized and effectively characterized by microwave irradiation technique and spectrsocopic means respectively . The in vitro antimicrobial screening of the targeted hydrazide-hydrazones 4a-l alongside with gentamicin (clinical standard) against six microorganisms was determined using agar diffusion. The result from the MIC test showed that this series of hydrazide-hydrazones exhibited remarkable efficacy as antimicrobial agents with 4e being the most active antibacterial agent
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Why is it important?
It brings to the fore and unveil novel heterocyclic moieties with highly significant biological activities essential in future drug development
Perspectives
From my perspective, the publication has contributed to the body of knowledge in organic synthesis and medicinal chemistry for therapeutic diversity
Prof. Olayinka Oyewale AJANI
Covenant University
Read the Original
This page is a summary of: Microwave Assisted Synthesis and Antimicrobial Potential of Quinoline-Based 4-Hydrazide-Hydrazone Derivatives, Journal of Heterocyclic Chemistry, November 2017, Wiley,
DOI: 10.1002/jhet.3050.
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