What is it about?
MARCKS and its relative MARCKSL1 are proteins relevant to many cellular processes, including development. We have shown for the first time that there are 4 members of this family in the zebrafish, which in turn have different roles in neural development.
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Why is it important?
Developmental disorders related to MARCKS proteins lead to severe conditions such as anencephaly and spina bifida. A fine understanding of the roles of these pivotal proteins in neural tube closure and morphogenesis is vital for early diagnostic and treatment.
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This page is a summary of: Functional Diversification of the Four MARCKS Family Members in Zebrafish Neural Development, Journal of Experimental Zoology Part B Molecular and Developmental Evolution, August 2016, Wiley,
DOI: 10.1002/jez.b.22691.
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