What is it about?
Our findings indicate that PC3/Tis21 inhibits cell proliferation in a way dependent on the presence of HDACs, in fibroblasts as well as in neural cells.
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Why is it important?
Considering that several reports have demonstrated that HDACs can act as transcriptional corepressors on the cyclin D1 promoter, our data suggest that the association of PC3/Tis21 to HDACs is functional to recruit them to target genes, such as cyclin D1, for repression of their expression.
Perspectives
HDACs are emplyed in tumor therapy and Tis21/Btg2 is a tumor suppressor
Dr Felice Tirone
National Research Council Italy
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This page is a summary of: HDAC1, HDAC4, and HDAC9 Bind to PC3/Tis21/Btg2 and Are Required for Its Inhibition of Cell Cycle Progression and Cyclin D1 Expression, Journal of Cellular Physiology, January 2017, Wiley,
DOI: 10.1002/jcp.25467.
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