What is it about?
cyclization of Schiff bases with thioglycollic acid in the presence of a catalytic amount of ZnCl2 yielded novel thiophene derivatives. Condensation of 2‐substituted‐4‐methylythio semi‐carbazides with carbonyl compounds under strong acidic conditions afforded 2‐thiazolines.
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Why is it important?
the synthesis of different thiophene, pyrazole, and thiazole derivatives according to different methods such as with various Schiff bases which on cyclization with thioglycollic acid in catalytic amount of ZnCl2 yielded novel thiophene derivatives. Condensation of 2-substituted-4-methylythio semicarbazides with carbonyl compounds under strong acidic conditions afforded 2-thiazolines. Also, carboxylic acids could react with 2-thioethylamine in the presence of triphenylphosphine and triethylamine to afford 2-thiazolines
Perspectives
I hope this article makes what people might think is a boring, slightly abstract area like synthesis of Synthesis of Thiophene, Pyrazole, and Thiazole Derivatives.
Dr. Nadia Ali Ahmed Elkanzi
Al-Jouf University
Read the Original
This page is a summary of: Short Review on the Synthesis of Thiophene, Pyrazole, and Thiazole Derivatives, Journal of the Chinese Chemical Society, November 2017, Wiley,
DOI: 10.1002/jccs.201700207.
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