Early endocrine and molecular changes in metabolic syndrome models

What is it about?

A general description of the metabolic syndrome and models used to its study; and particularly a rat model generated by sugar-rich beverage and normal chow in our laboratory. In addition, we describe some molecular changes observed in this model- insulin-secreting cells (pancreatic beta cells) at an early phase that could explain hyperinsulinemia in metabolic syndrome.

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Why is it important?

This review describes early molecular changes in beta cells in an early phase of metabolic syndrome in a rat model and proposes how these changes could be related with insulin hypersecretion. The study brings out a more comprehensive view of the beta-cell pathophysiology progression fro metabolic syndrome to type 2 diabetes mellitus.