What is it about?
Syndecan-2 is a cell-surface proteoglycan (protein decorated with glycosaminoglycan chains). This paper discusses how syndecan-2 participates in signaling that regulate cancer cell behaviour. We highlight that the role of syndecan-2 is different in tumors that have epithelial origin as compared to those originating from mesenchyme.
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Why is it important?
Since the role of syndecan in cancer pathogenesis is dependent on the tumor tissue origin it is a feasible biomarker/therapeutic target.
Perspectives
Hopefully this article can show possibilities for new therapeutic strategies.
George Tzanakakis
Medical School, University of Crete
Read the Original
This page is a summary of: Emerging roles of syndecan 2 in epithelial and mesenchymal cancer progression, IUBMB Life, September 2017, Wiley,
DOI: 10.1002/iub.1678.
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