What is it about?
A review of add-on ondansetron and other 5-HT3 antagonists in the treatment of obsessive-compulsive disorder (OCD). The work reviews also animal studies of the role of 5-HT3 receptor in the pathophysiology of OCD and attempts (unsuccessfully) to bridge animal with human studies. The current evidence about the usefulness of 5-HT3 antagonists added on ongoing antiobsessional treatment is far from being definitive and does not match animal evidence.
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Why is it important?
It shows that animal models quite don't match human models of OCD. It also provides a summary of all human experimentation in this field.
Perspectives
We need more human studies of 5-HT3 antagonists in OCD patients to acquire definitive data.
Dr Georgios D. Kotzalidis
Sapienza University, NESMOS Department
Read the Original
This page is a summary of: Are 5-HT3antagonists effective in obsessive-compulsive disorder? A systematic review of literature, Human Psychopharmacology Clinical and Experimental, February 2015, Wiley,
DOI: 10.1002/hup.2461.
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