growth hormone deficiency increases liver fibrosis

What is it about?

GH resistance increases liver fibrosis in a mouse model of inflammatory cholestasis, but decreases tumor incidence, indicating that loss of Ghr signaling may slow the progression from fibrosis/cirrhosis to cancer in the liver.

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Why is it important?

GH resistance dramatically exacerbates liver fibrosis in a mouse model of inflammatory cholestasis, therefore suggesting that GH resistance plays a causal role in the disease and provides a novel target for the development of liver fibrosis treatments.