What is it about?
Many naturally derived compounds are currently used in oncotherapy. Besides official medicine, complementary and alternative medicine practices, including old herbal remedies, are widely used and accepted as additional tools in cancer treatment. Angelica gigas Nakai (AGN), a medicinal herb in Asia, has roots historically used in medicine. This review focuses on key bioactive compounds from AGN roots – decursin, decursinol angelate (DA), and decursinol (DOH). Exploring their source, biosynthesis, and therapeutic mechanisms, the review highlights their role in cancer treatment. Biotechnological strategies for enhanced production and semisynthetic derivatives with anticancer properties are discussed. The study emphasizes the promising pharmacological potential of decursin, DA, and DOH in various therapeutic applications, particularly cancer treatment. The review also underscores innovative approaches to increase production and explores semisynthetic derivatives as a promising avenue for future natural product-based drug discovery. This concise overview provides valuable insights into the potential of AGN-derived compounds in the field of natural product-based therapeutics.
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Why is it important?
The article explores the potential of these compounds in cancer treatment by reviewing their molecular mechanisms and therapeutic effects. These compounds demonstrate anticancer activities by influencing various biological pathways involved in cancer progression, such as inhibiting angiogenesis, inducing apoptosis, and modulating immune responses. The article also discusses biotechnological strategies to enhance the production of these compounds and the development of semisynthetic derivatives to improve their therapeutic effectiveness. The review highlights the importance of natural product-based drug discovery and the promising role of decursin, DA, and DOH in developing new treatments for cancer, paving the way for future research and clinical applications.
Perspectives
The article provides several important perspectives regarding the anticancer potential of decursin, decursinol angelate (DA), and decursinol (DOH) from Angelica gigas Nakai: Natural Products as Cancer Therapeutics: The review highlights the importance of exploring natural compounds, such as decursin, DA, and DOH, in cancer treatment. These compounds offer a promising alternative to synthetic drugs due to their unique ability to target multiple pathways involved in cancer progression, with fewer side effects compared to conventional therapies. Biotechnological Advancements: There is a strong emphasis on using biotechnology to enhance the production of these compounds. This perspective suggests that improving production methods, such as using transgenic plant cultures and biotechnological strategies, could help scale the availability of these bioactive compounds for therapeutic use. Potential for Drug Development: The article explores how semisynthetic derivatives of decursin and related compounds could be developed to increase their anticancer efficacy. This opens up possibilities for more potent and targeted cancer treatments based on natural products. Molecular Mechanisms of Action: Understanding the detailed molecular pathways through which decursin, DA, and DOH exert their anticancer effects is a key perspective. By modulating pathways like protein kinase C, hypoxia-inducible factors, and angiogenesis, these compounds hold promise in treating various types of cancer and related conditions. Complementary Role in Cancer Therapy: The article views these compounds as complementary to conventional cancer therapies, potentially enhancing treatment efficacy and reducing toxicity. This perspective could shape future cancer treatment strategies, combining natural compounds with existing therapies.
Dr Javad Sharifi Rad
Universidad Espíritu Santo
Read the Original
This page is a summary of: Anticancer potential of decursin, decursinol angelate, and decursinol from Angelica gigas Nakai: A comprehensive review and future therapeutic prospects, Food Science & Nutrition, July 2024, Wiley,
DOI: 10.1002/fsn3.4376.
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