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This new probe is able to monitor soluble oligomeric aggregates after 24 h, at which time ThioflavinT emission, commonly used to monitor amyloid fibril formation, remains unchanged. Early detection of soluble toxic aggregates is important for early diagnosis of the so-called protein misfolding diseases such as Alzheimer.
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This page is a summary of: (E)‐2‐Cyano‐3‐(5′‐piperidin‐1‐yl‐2,2′‐bithien‐5‐yl)acrylic Acid: A Fluorescent Probe for Detecting Prefibrillar Oligomers, European Journal of Organic Chemistry, April 2013, Wiley,
DOI: 10.1002/ejoc.201300241.
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