What is it about?
This is a survey of the literature on magnetic resonance imaging (MRI) contrast agent based on iron. Thier specificity, properties and visual contrast effects are presented. The results were recorded both in vitro on simple tests and in vivo on living organisms. Appropriate theories of the contrast agent action and an outlook is presented.
Featured Image
Why is it important?
This is already another 15 years of investigations on the alternative models of MRI contrast agents. The commonly used gadolinium compounds have their drawback from the exogenous character and thus unknown biochemistry. Here, the compounds with iron - an natural, endogenous metal are proposed.
Perspectives
This work establishes a milestone and a good background for further development of iron contrast agents. The described models have already entered into the field of smart contrast agents, which behave as molecular probes changing their properties upon the action of a stimulus. We are currently working on such models.
Dr Nikodem Kuźnik
Silesian University of Technology
Read the Original
This page is a summary of: Iron(III) Contrast Agent Candidates for MRI: a Survey of the Structure-Effect Relationship in the Last 15 Years of Studies, European Journal of Inorganic Chemistry, December 2015, Wiley,
DOI: 10.1002/ejic.201501166.
You can read the full text:
Contributors
The following have contributed to this page
