What is it about?
Self-reactive CD8+ T cells that have been inactivated through a process that involves CD8 downregulation and expression of inhibitory molecules are found in healthy mice in the double negative PD-1+ population.
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Why is it important?
Our findings demonstrate that CD8 downregulation and PD-1 expression represent an ongoing mechanism of peripheral tolerance that keeps self-reactive CD8 T cells at bay
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This page is a summary of: Pro-inflammatory self-reactive T cells are found within murine TCR-αβ+CD4−CD8−PD-1+cells, European Journal of Immunology, April 2016, Wiley,
DOI: 10.1002/eji.201546056.
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