What is it about?
The ChgA 29–42 peptide from the N-terminal region of chromogranin A (ChgA) is able to induce cellular and humoral immune responses in type 1 diabetes prone NOD mice.Moreover, sera from diabetic NOD mice showed elevated titers of autoantibodies to this peptide.
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Why is it important?
The N-terminal region peptide of chromogranin A (ChgA) is able to induce cellular and humoral immune responses in type 1 diabetes prone NOD mice. This may be a new biomarker for type 1 diabetes.
Perspectives
The ChgA 29–42 peptide from the N-terminal region of chromogranin A (ChgA) is able to induce cellular and humoral immune responses in type 1 diabetes prone NOD mice.Moreover, sera from diabetic NOD mice showed elevated titers of autoantibodies to this peptide.
Dr Bhagirath Singh
Western University
Read the Original
This page is a summary of: Vasostatin-1 antigenic epitope mapping for induction of cellular and humoral immune responses to chromogranin A autoantigen in NOD mice, European Journal of Immunology, January 2014, Wiley,
DOI: 10.1002/eji.201343986.
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