Current knowledge of the immune system of the amphibian Xenopus.

What is it about?

This is an overview of the current knowledge and understanding of the immune system in the amphibian Xenopus. The immune system of tadpoles and adult frog is described in detail. Animals and reagents available are listed. Information about immune gene expression and their conservation with mammalian immune genes is provided.

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Why is it important?

Xenopus is an important comparative animal model. Its whole genome sequence and annotation, as well as the strains of inbred MHC defined animals, transgenic strains and reagents, cell lines (lympoid tumors, fibroblast) and reagents (monoclonal antibody, validated primers) makes this animal model powerful for fundamental biomedical research.