What is it about?
This publication is the first direct comparison of two ADM commercial products using histology, quantitation of fibroblast infiltration, elastin, collagen and mRNA analysis of type I collagen, fibronectin and Vegf-A. In addition, the healing characteristics in male and female rats were compared in compliance with the NIH guidelines for using gender as a variable.
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Why is it important?
Many acellular dermal matrices (ADMs) are available for use in periodontal surgical procedures. However, few studies exist evaluating their in vivo healing properties. The objectives of this study were to compare the wound healing and remodeling of two ADMs used for gingival augmentation procedures in the rat model. AlloDerm Regenerative Tissue Matrix, was compared to OrACELL. Gingival tissue from one mandibular quadrant served as the untreated control.
Perspectives
Early wound healing and remodeling of OrACELL appeared to occur more rapidly than AlloDerm and was accelerated in male rats. Whether these results have clinical implications for soft tissue grafting procedures in humans remains to be determined.
Regents Professor Kathy K. H. Svoboda
Texas A&M College of Dentistry
Read the Original
This page is a summary of: An in vivo comparison of wound healing characteristics of two commercial acellular dermal matrices, Clinical and Experimental Dental Research, May 2021, Wiley,
DOI: 10.1002/cre2.412.
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