What is it about?
Vibrational circular dichroism (VCD) spectroscopy has emerged as one of the most reliable spectroscopic techniques for investigating the absolute configuration of chiral molecules.1–3 In particular, in combination with density functional theory (DFT) calculations,4 VCD has made it possible to determine the relative configuration of chiral molecules possessing multiple chiral centers, such as in natural products, or to monitor various forms of configuration, planar, axial, central, and so on.5–13
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Why is it important?
VCD, like most forms of vibrational spectroscopies, is more adequate to discriminate various sources of chirality within molecular systems. Moreover due to its higher sensitivity, VCD can help to investigate conformational aspects as well, whose contributions are often hidden in ECD spectra. VCD spectroscopy has been increasingly appreciated outside the fields in which the technique was initially developed, namely, the spectroscopic chemical-physical field.
Perspectives
We can appreciate here the peculiar value of the VCD in defining local molecular chiral effects, in this sense the VCD can be considered an important almost sine-qua-non addition, as in the present case, to OR (in this case) and to the ECD (in general), the latter methods highlighting information on the chirality with a more global or overall character. More specifically, in the present case, OR is noted to be determined by a synergistic effect due to the central chirality of the outer group and the chirality of the metal, while VCD is more specific to the different forms of chirality.
Former Full Professor Renzo Ruzziconi
University of Perugia
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This page is a summary of: Mid‐IR and CH stretching vibrational circular dichroism spectroscopy to distinguish various sources of chirality: The case of quinophaneoxazoline based ruthenium(II) complexes, Chirality, February 2024, Wiley,
DOI: 10.1002/chir.23649.
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