ChemInform Abstract: Synthesis of Functionalized Pyrrole and Indole Derivatives Through Carbometalation of Lithiated Double Bonds.

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In conclusion, we have described an efficient conversion of dilithiated compounds, derived from bis(2-bromoallyl)amines, to dihydropyrrole derivatives by using TMEDA or catalytic amounts of CuCN, representing, as far as we know, the first intramolecular carbometalation of lithiated double bonds. In addition, a simple and straightforward synthesis of indoles has been also developed on the basis of this strategy.

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