how to substitute cubane

What is it about?

Very simple: How to attach something, to the corners of the molecular cubane.

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Why is it important?

Chemists have rolled the dice and worked with cubanes since its first synthesis by Eaton in 1964. Yet it's synthetic chemistry never took off, due to the problem of attaching residues to the corners, in chemist' speak to achieve C-H activation for C-C coupling reactions. Interest in cubanes has been renewed recently as it can be used as a bioisoswtere to benzene in drug candidates. Likewise, cubane offers significant potential as a strucutrally defined, yet nonconducting molecular building block in modern materials chemistry.