What is it about?
Neurons are specialised cells for transmitting nerve impulses and to monitor them firing is challenging. We have developed a new series of fluorescent BODIPY dyes that respond to the voltage changes that occur during the firing process. Unlike other commercial dyes they are neutral and the mechanism by which they work is very different.
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Why is it important?
The dyes we have developed are the first based on the BODIPY chromophore and are only slightly toxic to the neurons.
Perspectives
The work is a joint venture with workers from Keele University and is showing us new ways to improve the voltage sensitive response for next generation dyes.
Professor Andrew Christopher Benniston
Newcastle University
Read the Original
This page is a summary of: Locally Excited State-Charge Transfer State Coupled Dyes as Optically Responsive Neuron Firing Probes, Chemistry - A European Journal, September 2017, Wiley,
DOI: 10.1002/chem.201703366.
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