Retro-Brook Rearrangement of Ferrocene-Derived Silyl Ethers

What is it about?

We have shown that a silyl group from oxygen migrate to neighbouring carbanion centre on ferrocenyl derivatives. Carbanion centre can be obtained by Br-Li exchange as well as by diastereoselective ortho-lithiation.

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Why is it important?

Ferrocenyl silicon containing derivatives are useful in the synthesis of chiral ferrocenyl ligands. We have shown that retro-Brook rearrangement initiated by diastereoselective lithiation can lead to interesting chiral derivatives.