What is it about?
Environmental pollutants like PCB s are known for their ability to cumulate, persist in environment and cause adverse effects in many species. However, little is known about the pattern in which they cumulate especially in short periods after inhalation dosing. To achieve this objective, we have attempted to dose a commercial PCB mixture via inhalation route. We have estimated the pharmacokinetics of PCB based on plasma concentrations of two representative PCB congeners - PCB 77 (A dioxin like, less lipophillic, low chlorine PCB) and PCB 180 (A lipophillic, high chlorine, planar PCB) at different time-points in mice.
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Why is it important?
Chemical mixtures like PCBs cause pollution and health effects after they accumulate and magnify in the environment. They simply persist due to their chlorinated chemistry and high lipophilic nature, especially in human beings and aquatic organisms. Humans can be exposed to such pollutants inspite of their restricted manufacture, use and export, via dermal, inhalation and oral routes. Of these inhalation route holds significant responsibility for occupational exposures especially in machinery and electronic manufacturing units, causing significant morbidity. We have successfully estimated two such PCB congeners in blood as a fast method of biomonitoring in mouse models.
Perspectives
Other methods of bio monitoring of PCB and their mixtures exist but are costly and time consuming. They can detect more congeners but do not account for the estimation of PCBs from homolog families with diverse physicochemical characteristics. Hence, our method can be reproduced and is novel, rapid and cost effective method to detect both coplanar and o-substituted PCB congeners in a parallel manner using liquid chromatography methods.
Dr RAMANUJAM NARAYANAN
PSG INSTITUTE OF MEDICAL SCIENCES & RESEARCH
Read the Original
This page is a summary of: Fast and parallel determination of PCB 77 and PCB 180 in plasma using ultra performance liquid chromatography with diode array detection: A pharmacokinetic study in Swiss albino mouse, Biomedical Chromatography, June 2017, Wiley,
DOI: 10.1002/bmc.4000.
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