What is it about?
L-pipecolate is an important precursor of secondary metabolites some of which have pharmacological activities (e.g. the immunosuppressant rapamycin or the antitumor agent swainsonine). L-pipecolate can now be produced by fermentation from simple media.
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Why is it important?
Competing production options e.g. suffer from low conversion yields (chemistry) or require very high enzyme loading due to the low turnover numbers (biocatalysis).
Perspectives
L-pipecolate production from glycerol was very efficient. This may be very relevant if crude glycerol (e.g. the waste prodcut of the biodiesel process) can be used for L-pipecolate production.
Professor Volker F Wendisch
Universitat Bielefeld
Read the Original
This page is a summary of: Fermentative production of L-pipecolic acid from glucose and alternative carbon sources, Biotechnology Journal, March 2017, Wiley,
DOI: 10.1002/biot.201600646.
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