Ni(II) and Cu(II) complexes: Synthesis and Biological Studies

What is it about?

A new chelating agent, ((E)-2-((E)-2-hydroxynaphthalen-2-ylimino)methyl)-5-nitrophenylimino) indolin-2-one)) and its complexes with Ni(II) and Cu(II) ions have been prepared and characterized. Analytical and spectral data revealed that ligand was coordinated to the central metal ions by its two imine nitrogen, phenolic oxygen atom and carbonyl group with 1: 1: 1 stoichiometry. Spectral characterization of the novel complexes showed that Cu(II) and Ni(II) ions with HL ligand forms octahedral complexes where the ligand acts as tetradentate. Geometry optimization and conformational analysis have been performed and the model agreement with spectral studies allow for suggesting the exact structure of all studies complexes. The stability of complexes was discussed and kinetic parameters (E*, A, ΔH*, ΔS* and ΔG*) of all the thermal decomposition stages have been estimated using Coats - Redfern method. The synthesized complexes interact with DNA via intercalation mode and exhibited higher binding constant than classical intercalator. The antimicrobial screening assay of the compounds revealed variable activities towards the studied bacterial and fungal organisms.

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