What is it about?
This manuscript is about molecules that can bind DNA which have potential to enable the delivery of therapeutic DNA across cell membranes (i.e. act as artificial viruses).
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Why is it important?
The structures described used branched (tree-like) molecules displaying multiple copies of a biologically occuring polyamine (spermine) to bind DNA. The structures bound DNA very strongly because of this multivalent binding motif.
Perspectives
This manuscript describes preliminary studies of branched (tree-like) molecules displaying multiple copies of a biologically occuring polyamine (spermine) to bind DNA. The structures bound DNA very strongly because of this multivalent binding motif. This was the first time I had the opportunity to work with Mauri Kostiainen, who is now a good friend.
Dr John George Hardy
Lancaster University
Read the Original
This page is a summary of: High-Affinity Multivalent DNA Binding by Using Low-Molecular-Weight Dendrons, Angewandte Chemie International Edition, April 2005, Wiley,
DOI: 10.1002/anie.200500066.
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