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An easy way to synthesis of substituted quinolines is described. Simple reaction of aldehyde, amine and styrenes in the presence of iron(III) chloride afford quinolines in high yields.

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Why is it important?

The method is very simple and proceeds with easily available starting materials.

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This page is a summary of: Synthesis of Substituted Quinolines by Iron(III)‐Catalyzed Three‐Component Coupling Reaction of Aldehydes, Amines, and Styrenes, Asian Journal of Organic Chemistry, February 2014, Wiley,
DOI: 10.1002/ajoc.201300262.
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