PATIENT CONDITION MAY BE MORE IMPORTANT FOR SURVIVAL THAN MUTATIONAL ANALYSIS IN MDS

What is it about?

MDS patients have a very different prognosis, something usually calculated by the International Prognostic Scoring System revised (IPSS-R), that takes into account the presence and type of underlying genetic abnormalities, the proportion of bone marrow blasts as well as the number and depth of PB cytopenia. But this happens in a whole individual with his/her own personal life story before MDS diagnosis and this fact has been somehow neglected.

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Why is it important?

The Spanish MDS Group (Grupo Español de Síndromes Mielodisplásicos, GESMD) has found that the prognostic impact of patient condition overrides that of mutational analysis for survival prediction, while mutational analysis was the most relevant when predicting leukemic transformation. This paper highlights the importance of considering the whole individual when facing an older adult with MDS.